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KMID : 0387420090200020031
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Korean Society of Oriental Neuropsychiatry
2009 Volume.20 No. 2 p.31 ~ p.46
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Effect of Gojineumja(Guzhenyinzi) on Neural Tissue Degeneration in Mouse Model of Alzheimer Disease
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Lee Sang-Ryong
Jung In-Chul
Kim Hyun-Ju
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Abstract
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Objectives: This experiment was designed to investigate the effect of Gojineumja(Guzhenyinzi, GJEJ) on damaged neural tissue in cultured glial cells and in the mouse brain tissue.
Methods: The effects of the GJEJ on activation of astrocytes and caspase 3-positive cell counts in cultured glial cells administered with β-amyloid peptide were investigated. The effects of the GJEJ on levels of glial fibrillary acidic protein(GFAP)-positive reactive astrocyets and caspase 3-positive cells in the hippocampal subfields in the rats administered with scopolamine were investigated.
Results: 1. GJEJ reduced levels of activated astrocytes and caspase 3-positive cell counts in cultured glial cells administered with β-amyloid peptide. 2. GJEJ reduced levels of GFAP-positive reactive astrocyets and caspase 3-positive cells in the hippocampal subfields in the rats administered with scopolamine.
Conclusions: The present data suggest that GJEJ may have a protective function of neuronal and non-neuronal cells in damaged neural tissue caused by AD-like stimulations. Further studies on identification of effective molecular components of GJEJ and their interactions with damaged neural cells would be important for understanding molecular mechanism and may be further applicable for the development of therapeutic strategies.
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KEYWORD
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Alzheimer’s disease(AD), Gojineumja(GJEJ), GFAP, Caspase 3
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